caa a22 4500 605536341 CHVBK 20210128100852.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10517-015-3048-9 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3048-9 Brattleboro Rats as the Model of Blood Hyperviscosity Syndrome for Testing Substances with Hemorheological Activity [Elektronische Daten] [M. Plotnikov, A. Vasil'ev, O. Aliev, L. Zibareva] Hyperviscosity syndrome was described in Brattleboro rats. The aim of this study was to investigate the possibility of Brattleboro rats using, as a test system for the study of agents with hemorheological activity. Under conditions of this model of high blood viscosity syndrome in Brattleboro rats, Lychnis chalcedonica L. extract (150 mg/kg) administered intragastrically for 10 days exhibited hemorheological activity by modulating macro- (plasma viscosity, fibrinogen concentration) and microrheological (erythrocyte aggregation and deformability parameters. Hence, Brattleboro rats are an adequate model of hyperviscosity syndrome that can be used for search and testing of substances with hemorheological activity. Springer Science+Business Media New York, 2015 hereditary hypothalamic diabetes insipidus nationallicence Brattleboro rats nationallicence Lychnis chalcedonica extract nationallicence high blood viscosity syndrome nationallicence erythrocyte aggregation and deformability nationallicence Plotnikov M. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Vasil'ev A. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Aliev O. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Zibareva L. National Research Tomsk State University, Tomsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 689-691 0007-4888 159:5<689 2015 159 10517 https://doi.org/10.1007/s10517-015-3048-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3048-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Plotnikov M. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Vasil'ev A. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Aliev O. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Zibareva L. National Research Tomsk State University, Tomsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 689-691 0007-4888 159:5<689 2015 159 10517