caa a22 4500 605536414 CHVBK 20210128100852.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10517-015-3042-2 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3042-2 Tikhonov E. Research Institute of Human Morphology, Russian Academy of Sciences, Moscow, Russia aut Structural Changes in Large Intestinal Aggregated Lymphoid Follicles in Wistar Rats During Postnatal Ontogeny [Elektronische Daten] [E. Tikhonov] Quantitative evaluation of aggregated lymphoid follicles in various compartments of the large intestine was carried out in Wistar rats of different age: newborn (3-4 days), prepubertal (20-30 days), adult (2-3 months), and old (16-18 months). No aggregated lymphoid tissue was detected in the large intestinal mucosa of newborn animals. The cecum of prepubertal, adult, and old animals contained solitary patches with 7-9 follicles. Higher percentage of aggregated lymphoid tissue, associated with colonic mucosa, was explained by enlargement of the lymphoid patch area and of the number of solitary lymphoid follicles during the postnatal ontogenesis. The mean area of a patch in the distal part of the colon in prepubertal, adult, and old animals was 3.2, 2.5, and 2.2 times larger than in the medial part of the intestine, the number of follicles per patch was 2.8, 2.8, and 2.5 times higher, respectively. The differences were significant only for the two younger groups. Springer Science+Business Media New York, 2015 lymphoid tissue nationallicence large intestine nationallicence postnatal development periods nationallicence rat nationallicence Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 662-665 0007-4888 159:5<662 2015 159 10517 https://doi.org/10.1007/s10517-015-3042-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3042-2 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Tikhonov E. Research Institute of Human Morphology, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/5(2015-09-01), 662-665 0007-4888 159:5<662 2015 159 10517