Effect of Nitric Oxide Synthesis Blockade on the Morphology of Langerhans Islets in August and Wistar Rats with Acute Alloxan Diabetes
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2940-7 |2 doi |
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| 245 | 0 | 0 | |a Effect of Nitric Oxide Synthesis Blockade on the Morphology of Langerhans Islets in August and Wistar Rats with Acute Alloxan Diabetes |h [Elektronische Daten] |c [E. Smirnova, A. Michunskaya, O. Terekhina, L. Kobozeva, S. Kruglov, L. Belkina, O. Pozdnyakov] |
| 520 | 3 | |a Alloxan diabetes was modeled in August rats with high activity of the NO system and in Wistar rats, and the effects of NO system blockade (by a course treatment with L-NNA) on Langerhans islet β cells were studied in 15 days. The toxic effects of diabetes on the rat β cells and islets were similar: the content of active β cells in the islets decreased to 15-20%, the number of islets to 24-29% of control. A course of L-NNA reduced the β cell and islet death, in August cells greater than in Wistar: the number of islets in August rats was restored to 81%, in Wistar rats to 60% of initial level; the activity of β cells remained at the control level in the former and 2-fold lower than in the control in the latter. It seems that a less pronounced protective effect of L-NNA in Wistar rats was explained by excessive reduction of NO level essential for β cell regeneration. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a alloxan |2 nationallicence | |
| 690 | 7 | |a Langerhans islets |2 nationallicence | |
| 690 | 7 | |a nitric oxide |2 nationallicence | |
| 700 | 1 | |a Smirnova |D E. |u Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Michunskaya |D A. |u Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Terekhina |D O. |u Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Kobozeva |D L. |u Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Kruglov |D S. |u Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Belkina |D L. |u Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 700 | 1 | |a Pozdnyakov |D O. |u Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/2(2015-06-01), 273-277 |x 0007-4888 |q 159:2<273 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2940-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2940-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Smirnova |D E. |u Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Michunskaya |D A. |u Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Terekhina |D O. |u Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kobozeva |D L. |u Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kruglov |D S. |u Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Belkina |D L. |u Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pozdnyakov |D O. |u Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/2(2015-06-01), 273-277 |x 0007-4888 |q 159:2<273 |1 2015 |2 159 |o 10517 | ||