caa a22 4500 605536465 CHVBK 20210128100852.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10517-015-2940-7 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2940-7 Effect of Nitric Oxide Synthesis Blockade on the Morphology of Langerhans Islets in August and Wistar Rats with Acute Alloxan Diabetes [Elektronische Daten] [E. Smirnova, A. Michunskaya, O. Terekhina, L. Kobozeva, S. Kruglov, L. Belkina, O. Pozdnyakov] Alloxan diabetes was modeled in August rats with high activity of the NO system and in Wistar rats, and the effects of NO system blockade (by a course treatment with L-NNA) on Langerhans islet β cells were studied in 15 days. The toxic effects of diabetes on the rat β cells and islets were similar: the content of active β cells in the islets decreased to 15-20%, the number of islets to 24-29% of control. A course of L-NNA reduced the β cell and islet death, in August cells greater than in Wistar: the number of islets in August rats was restored to 81%, in Wistar rats to 60% of initial level; the activity of β cells remained at the control level in the former and 2-fold lower than in the control in the latter. It seems that a less pronounced protective effect of L-NNA in Wistar rats was explained by excessive reduction of NO level essential for β cell regeneration. Springer Science+Business Media New York, 2015 alloxan nationallicence Langerhans islets nationallicence nitric oxide nationallicence Smirnova E. Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Michunskaya A. Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Terekhina O. Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Kobozeva L. Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Kruglov S. Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Belkina L. Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Pozdnyakov O. Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/2(2015-06-01), 273-277 0007-4888 159:2<273 2015 159 10517 https://doi.org/10.1007/s10517-015-2940-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2940-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Smirnova E. Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Michunskaya A. Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Terekhina O. Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Kobozeva L. Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Kruglov S. Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Belkina L. Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Pozdnyakov O. Research Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/2(2015-06-01), 273-277 0007-4888 159:2<273 2015 159 10517