Effects of Immunoregulatory Cytokines (IL-2, IL-7, and IL-15) on Expression of Gfi1 and U2afll4 Genes in T Cells at Different Stages of Differentiation
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2931-8 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2931-8 | ||
| 245 | 0 | 0 | |a Effects of Immunoregulatory Cytokines (IL-2, IL-7, and IL-15) on Expression of Gfi1 and U2afll4 Genes in T Cells at Different Stages of Differentiation |h [Elektronische Daten] |c [N. Sokhonevich, K. Yurova, A. Gutsol, O. Khaziakhmatova, I. Mazunin, L. Litvinova] |
| 520 | 3 | |a Opposite effects of common γ-chain cytokines (IL-2, IL-7, and IL-15) on the expression of Gfi1 and U2af1l4 genes regulating alternative splicing of Ptprc gene in T cells at different stages of differentiation were demonstrated in vitro. Generally, produced a dose-dependent activating effect on T cells, while to the effects of rIL-7 and rIL-15 on T cells at different stages of differentiation were opposite to that of rIL-2: maximum concentrations of recombinant cytokines IL-7 and IL-15 produced the most pronounced inhibitory effect on U2af1l4 and to a lesser extent on Gfi1 gene expression, thus limiting activation of resting cells. This is consistent with their biological effects on T cells. In general, common γ-chain cytokines IL-2, IL-7, and IL-15 prevent differentiation of naïve T cells in vitro and limit activation of primed T cells in the absence of antigenic stimulus, which can contribute to the formation of cytokine imbalance. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a cytokines |2 nationallicence | |
| 690 | 7 | |a expression of Gfi1 and U2afll4 genes |2 nationallicence | |
| 690 | 7 | |a memory T cells |2 nationallicence | |
| 690 | 7 | |a naïve cells |2 nationallicence | |
| 690 | 7 | |a alternative splicing |2 nationallicence | |
| 700 | 1 | |a Sokhonevich |D N. |u Laboratory of Immunology and Cell Technologies, Innovation Park, I. Kant Baltic Federal University, Kaliningrad, Russia |4 aut | |
| 700 | 1 | |a Yurova |D K. |u Laboratory of Immunology and Cell Technologies, Innovation Park, I. Kant Baltic Federal University, Kaliningrad, Russia |4 aut | |
| 700 | 1 | |a Gutsol |D A. |u Laboratory of Immunology and Cell Technologies, Innovation Park, I. Kant Baltic Federal University, Kaliningrad, Russia |4 aut | |
| 700 | 1 | |a Khaziakhmatova |D O. |u Laboratory of Immunology and Cell Technologies, Innovation Park, I. Kant Baltic Federal University, Kaliningrad, Russia |4 aut | |
| 700 | 1 | |a Mazunin |D I. |u Laboratory of Immunology and Cell Technologies, Innovation Park, I. Kant Baltic Federal University, Kaliningrad, Russia |4 aut | |
| 700 | 1 | |a Litvinova |D L. |u Laboratory of Immunology and Cell Technologies, Innovation Park, I. Kant Baltic Federal University, Kaliningrad, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/2(2015-06-01), 236-239 |x 0007-4888 |q 159:2<236 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2931-8 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2931-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sokhonevich |D N. |u Laboratory of Immunology and Cell Technologies, Innovation Park, I. Kant Baltic Federal University, Kaliningrad, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yurova |D K. |u Laboratory of Immunology and Cell Technologies, Innovation Park, I. Kant Baltic Federal University, Kaliningrad, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gutsol |D A. |u Laboratory of Immunology and Cell Technologies, Innovation Park, I. Kant Baltic Federal University, Kaliningrad, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Khaziakhmatova |D O. |u Laboratory of Immunology and Cell Technologies, Innovation Park, I. Kant Baltic Federal University, Kaliningrad, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mazunin |D I. |u Laboratory of Immunology and Cell Technologies, Innovation Park, I. Kant Baltic Federal University, Kaliningrad, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Litvinova |D L. |u Laboratory of Immunology and Cell Technologies, Innovation Park, I. Kant Baltic Federal University, Kaliningrad, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/2(2015-06-01), 236-239 |x 0007-4888 |q 159:2<236 |1 2015 |2 159 |o 10517 | ||