Effect of Exogenous Extracellular Nicotinamide Adenine Dinucleotide (NAD+) on Bioelectric Activity of the Pacemaker and Conduction System of the Heart
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2919-4 |2 doi |
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| 245 | 0 | 0 | |a Effect of Exogenous Extracellular Nicotinamide Adenine Dinucleotide (NAD+) on Bioelectric Activity of the Pacemaker and Conduction System of the Heart |h [Elektronische Daten] |c [K. Pustovit, V. Kuz'min, G. Sukhova] |
| 520 | 3 | |a In rat sinoatrial node, NAD+ (10 μM) reduced the rate of spontaneous action potentials, duration of action potentials, and the velocity of slow diastolic depolarization, but the rate of action potential front propagation increases. In passed rabbit Purkinje fi bers, NAD+ (10 μM) reduced the duration of action potentials. Under conditions of spontaneous activity of Purkinje fi bers, NAD+ reduced the fi ring rate and the rate of slow diastolic depolarization. The effects of extracellular NAD+ on bioelectric activity of the pacemaker (sinoatrial node) and conduction system of the heart (Purkinje fi bers) are probably related to activation of P1 and P2 purinoceptors. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a sinoatrial node |2 nationallicence | |
| 690 | 7 | |a Purkinje fi bers |2 nationallicence | |
| 690 | 7 | |a action potential |2 nationallicence | |
| 690 | 7 | |a NAD+ |2 nationallicence | |
| 700 | 1 | |a Pustovit |D K. |u Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Kuz'min |D V. |u Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Sukhova |D G. |u Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/2(2015-06-01), 188-191 |x 0007-4888 |q 159:2<188 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2919-4 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2919-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Pustovit |D K. |u Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kuz'min |D V. |u Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sukhova |D G. |u Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/2(2015-06-01), 188-191 |x 0007-4888 |q 159:2<188 |1 2015 |2 159 |o 10517 | ||