caa a22 4500 605536546 CHVBK 20210128100853.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10517-015-2919-4 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2919-4 Effect of Exogenous Extracellular Nicotinamide Adenine Dinucleotide (NAD+) on Bioelectric Activity of the Pacemaker and Conduction System of the Heart [Elektronische Daten] [K. Pustovit, V. Kuz'min, G. Sukhova] In rat sinoatrial node, NAD+ (10 μM) reduced the rate of spontaneous action potentials, duration of action potentials, and the velocity of slow diastolic depolarization, but the rate of action potential front propagation increases. In passed rabbit Purkinje fi bers, NAD+ (10 μM) reduced the duration of action potentials. Under conditions of spontaneous activity of Purkinje fi bers, NAD+ reduced the fi ring rate and the rate of slow diastolic depolarization. The effects of extracellular NAD+ on bioelectric activity of the pacemaker (sinoatrial node) and conduction system of the heart (Purkinje fi bers) are probably related to activation of P1 and P2 purinoceptors. Springer Science+Business Media New York, 2015 sinoatrial node nationallicence Purkinje fi bers nationallicence action potential nationallicence NAD+ nationallicence Pustovit K. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia aut Kuz'min V. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia aut Sukhova G. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/2(2015-06-01), 188-191 0007-4888 159:2<188 2015 159 10517 https://doi.org/10.1007/s10517-015-2919-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2919-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pustovit K. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 700 1- Kuz'min V. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 700 1- Sukhova G. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/2(2015-06-01), 188-191 0007-4888 159:2<188 2015 159 10517