Chlamydia Pneumoniae and Immunoinflammatory Reactions in an Unstable Atherosclerotic Plaque in Humans

Verfasser / Beitragende:
[P. Pigarevskii, S. Mal'tseva, V. Snegova, N. Davydova, V. Guseva]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 159/2(2015-06-01), 278-281
Format:
Artikel (online)
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024 7 0 |a 10.1007/s10517-015-2941-6  |2 doi 
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245 0 0 |a Chlamydia Pneumoniae and Immunoinflammatory Reactions in an Unstable Atherosclerotic Plaque in Humans  |h [Elektronische Daten]  |c [P. Pigarevskii, S. Mal'tseva, V. Snegova, N. Davydova, V. Guseva] 
520 3 |a Comparative study of the walls of the aorta, coronary artery, and a. basilaris detected for the first time intra- and extracellular depositions of Chlamydia pneumoniae in unstable atherosclerotic plaques. No chlamydia were detected in the intima of normal sites of the vascular wall and just negligible levels thereof in stable atherosclerotic plaques. An unstable plaque with intra- and extracellular colonies was characterized by infiltration of the cap and intima adjacent to the atheromatous core with mononuclear cells, primarily T cells. These data suggested that Chlamydia pneumoniae could play an important role in the development of immunoinflammatory processes in the vascular wall and promote destabilization and progressive development of atherosclerotic plaques in humans. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a unstable atherosclerotic plaque  |2 nationallicence 
690 7 |a Chlamydia pneumoniae  |2 nationallicence 
690 7 |a T cells  |2 nationallicence 
690 7 |a immunoinflammatory reaction  |2 nationallicence 
700 1 |a Pigarevskii  |D P.  |u Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
700 1 |a Mal'tseva  |D S.  |u Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
700 1 |a Snegova  |D V.  |u Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
700 1 |a Davydova  |D N.  |u Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
700 1 |a Guseva  |D V.  |u Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Pigarevskii  |D P.  |u Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Mal'tseva  |D S.  |u Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Snegova  |D V.  |u Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Davydova  |D N.  |u Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Guseva  |D V.  |u Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 159/2(2015-06-01), 278-281  |x 0007-4888  |q 159:2<278  |1 2015  |2 159  |o 10517