caa a22 4500 605536589 CHVBK 20210128100853.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10517-015-2941-6 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2941-6 Chlamydia Pneumoniae and Immunoinflammatory Reactions in an Unstable Atherosclerotic Plaque in Humans [Elektronische Daten] [P. Pigarevskii, S. Mal'tseva, V. Snegova, N. Davydova, V. Guseva] Comparative study of the walls of the aorta, coronary artery, and a. basilaris detected for the first time intra- and extracellular depositions of Chlamydia pneumoniae in unstable atherosclerotic plaques. No chlamydia were detected in the intima of normal sites of the vascular wall and just negligible levels thereof in stable atherosclerotic plaques. An unstable plaque with intra- and extracellular colonies was characterized by infiltration of the cap and intima adjacent to the atheromatous core with mononuclear cells, primarily T cells. These data suggested that Chlamydia pneumoniae could play an important role in the development of immunoinflammatory processes in the vascular wall and promote destabilization and progressive development of atherosclerotic plaques in humans. Springer Science+Business Media New York, 2015 unstable atherosclerotic plaque nationallicence Chlamydia pneumoniae nationallicence T cells nationallicence immunoinflammatory reaction nationallicence Pigarevskii P. Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut Mal'tseva S. Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut Snegova V. Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut Davydova N. Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut Guseva V. Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/2(2015-06-01), 278-281 0007-4888 159:2<278 2015 159 10517 https://doi.org/10.1007/s10517-015-2941-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2941-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pigarevskii P. Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Mal'tseva S. Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Snegova V. Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Davydova N. Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Guseva V. Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/2(2015-06-01), 278-281 0007-4888 159:2<278 2015 159 10517