caa a22 4500 605536619 CHVBK 20210128100853.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10517-015-2943-4 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2943-4 Inherited Alopecia Areata in Mice as a Result of Adoptive Transfer of In Vivo Mitogen-Activated Splenic Cells to Females During Early Period of Gestation [Elektronische Daten] [N. Yaglova, S. Obernikhin] Postnatal morphogenesis of the skin and its appendages were studied in the progeny of mice subjected during early gestation period to adoptive transfer of in vivo activated splenic cells. Reversible focal hair loss was observed on postnatal day 17 in the progeny. The number of hair follicles and sebaceous glands, the level of extracellular matrix, and the content of cells in the skin, including mast cells in the derma, decreased, while neutrophils prevailed. Alopecia areata was found in the subsequent generations after mating of male and female progeny. Hence, stimulation of the maternal immune system during early pregnancy led to disorders of the pre- and postnatal morphogenesis of the skin in the progeny and to development of alopecia areata that became an inherited sign. Springer Science+Business Media New York, 2015 alopecia areata nationallicence prenatal exposure nationallicence skin nationallicence hair follicles nationallicence Yaglova N. Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia aut Obernikhin S. Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/2(2015-06-01), 285-288 0007-4888 159:2<285 2015 159 10517 https://doi.org/10.1007/s10517-015-2943-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2943-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yaglova N. Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Obernikhin S. Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/2(2015-06-01), 285-288 0007-4888 159:2<285 2015 159 10517