Experimental Model to Study the Role of Retinoblastoma Gene Product (pRb) for Determination of Adipocyte Differentiation
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2944-3 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2944-3 | ||
| 245 | 0 | 0 | |a Experimental Model to Study the Role of Retinoblastoma Gene Product (pRb) for Determination of Adipocyte Differentiation |h [Elektronische Daten] |c [B. Popov, P. Shilo, O. Zhidkova, A. Zaichik, N. Petrov] |
| 520 | 3 | |a Using stable constitutive expression of retinoblastoma gene product (pRb) in polypotent mesenchymal 10T1/2 cells we obtained stable cell lines hyperexpressing functionally active or inactive mutant pRb. The cells producing active exogenous pRb demonstrated high sensitivity to adipocyte differentiation inductors, whereas production of inactive form of the exogenous protein suppressed adipocyte differentiation. The obtained lines can serve as the experimental model for studying the role of pRb in determination of adipocyte differentiation. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a mesenchymal stem cells |2 nationallicence | |
| 690 | 7 | |a adipocyte differentiation |2 nationallicence | |
| 690 | 7 | |a pRb |2 nationallicence | |
| 700 | 1 | |a Popov |D B. |u Institute of Cytology, Russian Academy of Science, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Shilo |D P. |u Institute of Cytology, Russian Academy of Science, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Zhidkova |D O. |u Institute of Cytology, Russian Academy of Science, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Zaichik |D A. |u North-Western State Medical University, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Petrov |D N. |u Institute of Cytology, Russian Academy of Science, St. Petersburg, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/2(2015-06-01), 289-292 |x 0007-4888 |q 159:2<289 |1 2015 |2 159 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2944-3 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2944-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Popov |D B. |u Institute of Cytology, Russian Academy of Science, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shilo |D P. |u Institute of Cytology, Russian Academy of Science, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhidkova |D O. |u Institute of Cytology, Russian Academy of Science, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zaichik |D A. |u North-Western State Medical University, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Petrov |D N. |u Institute of Cytology, Russian Academy of Science, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 159/2(2015-06-01), 289-292 |x 0007-4888 |q 159:2<289 |1 2015 |2 159 |o 10517 | ||