caa a22 4500 605536635 CHVBK 20210128100853.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10517-015-2927-4 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2927-4 Effects of a Preparation Containing Pantogam, Succinic Acid, and Chitosan on Activities of the Glutathione System and NADPH-Generating Enzymes in Rat Tissues under Conditions of Cerebral Ischemia/Reperfusion [Elektronische Daten] [O. Safonova, T. Popova, A. Slivkin, Yu. Talmi] Treatment with the complex preparation containing pantogam, succinic acid, and chitosan normalized the concentration of reduced glutathione and activities of glutathione peroxidase, glutathione reductase, and some NADPH-generating enzymes (glucose-6-phosphate dehydrogenase and NADPH-isocitrate dehydrogenase) in animals with experimental hypoxia/reperfusion of the brain. These results can be explained by suppression of free radical oxidation and normalization of the antioxidant system related to the neuroprotective, antihypoxic, and antioxidant properties of these substances, their involvement into the regulation of cell metabolism under pathological conditions accompanied by oxidative stress. Springer Science+Business Media New York, 2015 pantogam nationallicence succinic acid nationallicence chitosan nationallicence brain ischemia/reperfusion nationallicence glutathione antioxidant system nationallicence Safonova O. Voronezh State University, Voronezh, Russia aut Popova T. Voronezh State University, Voronezh, Russia aut Slivkin A. Voronezh State University, Voronezh, Russia aut Talmi Yu Voronezh State University, Voronezh, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/2(2015-06-01), 221-224 0007-4888 159:2<221 2015 159 10517 https://doi.org/10.1007/s10517-015-2927-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2927-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Safonova O. Voronezh State University, Voronezh, Russia aut NATIONALLICENCE 700 1- Popova T. Voronezh State University, Voronezh, Russia aut NATIONALLICENCE 700 1- Slivkin A. Voronezh State University, Voronezh, Russia aut NATIONALLICENCE 700 1- Talmi Yu Voronezh State University, Voronezh, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/2(2015-06-01), 221-224 0007-4888 159:2<221 2015 159 10517