Expression of Pattern Recognition Receptors by Nociceptive Metasympathetic Neurons

Verfasser / Beitragende:
[L. Filippova, E. Bystrova, F. Malyshev, O. Platonova, A. Nozdrachev]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 159/2(2015-06-01), 248-252
Format:
Artikel (online)
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245 0 0 |a Expression of Pattern Recognition Receptors by Nociceptive Metasympathetic Neurons  |h [Elektronische Daten]  |c [L. Filippova, E. Bystrova, F. Malyshev, O. Platonova, A. Nozdrachev] 
520 3 |a Immunohistochemical assay with double label and confocal laser scanning microscopy showed that innate immunity receptor TLR4 is expressed predominantly in neurons of the intestinal Auerbach (myenteric) plexus, while vanilloid nociceptive receptor TRPV1 is expressed by neurons of Meissner (submucous) plexus. Immunohistochemical analysis with triple labeling revealed coexpression of TLR4 and TRPV1 in enteric neurons of rat colon. The results attest to a possibility of functional interaction between Toll-like and vanilloid receptors in the neuron level. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a intestine  |2 nationallicence 
690 7 |a neuron  |2 nationallicence 
690 7 |a TLR4  |2 nationallicence 
690 7 |a TRPV1  |2 nationallicence 
690 7 |a coexpression  |2 nationallicence 
700 1 |a Filippova  |D L.  |u I. P. Pavlov Institute of Physiology, Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
700 1 |a Bystrova  |D E.  |u I. P. Pavlov Institute of Physiology, Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
700 1 |a Malyshev  |D F.  |u I. P. Pavlov Institute of Physiology, Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
700 1 |a Platonova  |D O.  |u I. P. Pavlov Institute of Physiology, Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
700 1 |a Nozdrachev  |D A.  |u I. P. Pavlov Institute of Physiology, Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Bystrova  |D E.  |u I. P. Pavlov Institute of Physiology, Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Malyshev  |D F.  |u I. P. Pavlov Institute of Physiology, Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Platonova  |D O.  |u I. P. Pavlov Institute of Physiology, Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Nozdrachev  |D A.  |u I. P. Pavlov Institute of Physiology, Russian Academy of Medical Sciences, St. Petersburg, Russia  |4 aut 
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