caa a22 4500 605536686 CHVBK 20210128100853.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10517-015-2922-9 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2922-9 Factors of Th17 and Treg Lymphocyte Differentiation in Pulmonary Tuberculosis [Elektronische Daten] [T. Kononova, O. Urazova, V. Novitskii, Yu. Kolobovnikova, E. Churina, P. Zakharova] In patients with infiltrative pulmonary tuberculosis, the increase in IL-6 secretion, the decrease in TGFβ production (in case of drug resistance of the causative agent), and unchanged level of IL-1β secretion by mononuclear leukocytes in vitro were associated with increased number of CD4+CD161+IL-17A+ Th17 lymphocytes in the peripheral blood. In patients with disseminated drug-resistant pulmonary tuberculosis, TGFβ hyperproduction promoted differentiation of CD4+CD25+FoxP3+ Treg lymphocytes with immunosuppressive activity. Springer Science+Business Media New York, 2015 Th17 lymphocytes nationallicence Treg lymphocytes nationallicence cytokines nationallicence pulmonary tuberculosis nationallicence Kononova T. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut Urazova O. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut Novitskii V. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut Kolobovnikova Yu Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut Churina E. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut Zakharova P. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/2(2015-06-01), 201-204 0007-4888 159:2<201 2015 159 10517 https://doi.org/10.1007/s10517-015-2922-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2922-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kononova T. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Urazova O. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Novitskii V. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Kolobovnikova Yu Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Churina E. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 700 1- Zakharova P. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 159/2(2015-06-01), 201-204 0007-4888 159:2<201 2015 159 10517