caa a22 4500 605536708 CHVBK 20210128100854.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10517-015-3118-z doi (NATIONALLICENCE)springer-10.1007/s10517-015-3118-z Effect of Hypoxanthine on Functional Activity of Nucleoside Transporters ENT1 and ENT2 in Caco-2 Polar Epithelial Intestinal Cells [Elektronische Daten] [N. Senyavina, S. Tonevitskaya] We studied regulation of hypoxanthine transport depending on its concentration in the culture medium. Caco-2 cells were differentiated on membrane filters to create a model of the intestine. Different hypoxanthine uptake on the apical and basolateral cell membranes was observed. The expression of SLC29 family genes encoding passive nucleoside transporters increased upon changes in hypoxanthine concentration in the medium Localization of the transporters and their influence on the effect of pharmacological preparations are discussed. Springer Science+Business Media New York, 2015 metabolism of purines nationallicence hypoxanthine, purine re-synthesis pathway nationallicence Caco-2 nationallicence nucleoside transporters nationallicence Senyavina N. BioClinicum Research-and-Production Center, Moscow, Russia aut Tonevitskaya S. Moscow State Engineering University, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 160-164 0007-4888 160:1<160 2015 160 10517 https://doi.org/10.1007/s10517-015-3118-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3118-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Senyavina N. BioClinicum Research-and-Production Center, Moscow, Russia aut NATIONALLICENCE 700 1- Tonevitskaya S. Moscow State Engineering University, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 160-164 0007-4888 160:1<160 2015 160 10517