A Method for Detection of Cholesterol Synthesis in the Placenta during Exacerbation of Cytomegalovirus Infection

Verfasser / Beitragende:
[M. Lutsenko, I. Dovzhikova]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 160/1(2015-11-01), 174-177
Format:
Artikel (online)
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024 7 0 |a 10.1007/s10517-015-3120-5  |2 doi 
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245 0 2 |a A Method for Detection of Cholesterol Synthesis in the Placenta during Exacerbation of Cytomegalovirus Infection  |h [Elektronische Daten]  |c [M. Lutsenko, I. Dovzhikova] 
520 3 |a Histochemical analysis showed that exacerbation of cytomegalovirus infection even at early terms of gestation (weeks 5-6) suppresses synthesis of mevalonic acid, squalene, and 7α-dehydrocholesterol dehydrogenase in the placenta. Inhibition of cholesterol biosynthesis in the placenta at the early stages of gestation decreases production of sex hormones, reduces cholesterol concentration in the maternal peripheral blood, and impairs cholesterol supply to the fetus, which is associated with the risk of placental insufficiency. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a cholesterol  |2 nationallicence 
690 7 |a placenta  |2 nationallicence 
690 7 |a cytomegalovirus infection  |2 nationallicence 
700 1 |a Lutsenko  |D M.  |u Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia  |4 aut 
700 1 |a Dovzhikova  |D I.  |u Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia  |4 aut 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Lutsenko  |D M.  |u Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Dovzhikova  |D I.  |u Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 160/1(2015-11-01), 174-177  |x 0007-4888  |q 160:1<174  |1 2015  |2 160  |o 10517