caa a22 4500 605536716 CHVBK 20210128100854.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10517-015-3120-5 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3120-5 A Method for Detection of Cholesterol Synthesis in the Placenta during Exacerbation of Cytomegalovirus Infection [Elektronische Daten] [M. Lutsenko, I. Dovzhikova] Histochemical analysis showed that exacerbation of cytomegalovirus infection even at early terms of gestation (weeks 5-6) suppresses synthesis of mevalonic acid, squalene, and 7α-dehydrocholesterol dehydrogenase in the placenta. Inhibition of cholesterol biosynthesis in the placenta at the early stages of gestation decreases production of sex hormones, reduces cholesterol concentration in the maternal peripheral blood, and impairs cholesterol supply to the fetus, which is associated with the risk of placental insufficiency. Springer Science+Business Media New York, 2015 cholesterol nationallicence placenta nationallicence cytomegalovirus infection nationallicence Lutsenko M. Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia aut Dovzhikova I. Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 174-177 0007-4888 160:1<174 2015 160 10517 https://doi.org/10.1007/s10517-015-3120-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3120-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lutsenko M. Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia aut NATIONALLICENCE 700 1- Dovzhikova I. Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 174-177 0007-4888 160:1<174 2015 160 10517