Effects of Liposomal Compositions with Oxidized Dextrans on Functional Activity of U937 Macrophage-Like Cells In Vitro
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3097-0 |2 doi |
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| 245 | 0 | 0 | |a Effects of Liposomal Compositions with Oxidized Dextrans on Functional Activity of U937 Macrophage-Like Cells In Vitro |h [Elektronische Daten] |c [P. Kozhin, A. Chechushkov, N. Zaitseva, A. Lemza, E. Men'shchikova, A. Troitskii, V. Shkurupy] |
| 520 | 3 | |a We studied the effects of liposomal pharmaceutical compositions with oxidized dextrans on functional activity of U937 monocyte/macrophage-like cells. Liposomes in the emulsion contained oxidized dextran with a molecular weights of 40 kDa or 70 kDa or isonicotinic acid hydrazide (INAH) conjugated with oxidized dextran (40 kDa). Cell viability was evaluated by MTT test; mitochondrial transmembrane potential and production of superoxide anion and H2O2 were studied by fluorescent methods. The studied compositions exhibited no cytotoxic effect and even improved cell viability and mitochondrial respiration. Liposomes with oxidized 40 kDa dextran, including those with INAH-conjugated dextran, inhibited production of superoxide anion, but increased H2O2 generation. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a oxidized dextran |2 nationallicence | |
| 690 | 7 | |a isonicotinic acid hydrazide |2 nationallicence | |
| 690 | 7 | |a macrophages |2 nationallicence | |
| 690 | 7 | |a viability |2 nationallicence | |
| 690 | 7 | |a reactive oxygen species |2 nationallicence | |
| 700 | 1 | |a Kozhin |D P. |u Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Chechushkov |D A. |u Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Zaitseva |D N. |u Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Lemza |D A. |u Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Men'shchikova |D E. |u Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Troitskii |D A. |u Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia |4 aut | |
| 700 | 1 | |a Shkurupy |D V. |u Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 160/1(2015-11-01), 57-60 |x 0007-4888 |q 160:1<57 |1 2015 |2 160 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3097-0 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3097-0 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kozhin |D P. |u Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chechushkov |D A. |u Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zaitseva |D N. |u Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lemza |D A. |u Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Men'shchikova |D E. |u Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Troitskii |D A. |u Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shkurupy |D V. |u Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 160/1(2015-11-01), 57-60 |x 0007-4888 |q 160:1<57 |1 2015 |2 160 |o 10517 | ||