Activity of Glutathione Antioxidant System and NADPH-Generating Enzymes in Rats with Experimental Rheumatoid Arthritis
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3089-0 |2 doi |
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| 245 | 0 | 0 | |a Activity of Glutathione Antioxidant System and NADPH-Generating Enzymes in Rats with Experimental Rheumatoid Arthritis |h [Elektronische Daten] |c [E. Kryl'skii, T. Popova, E. Kirilova] |
| 520 | 3 | |a Induction of rheumatoid arthritis in rats was accompanied by an increase in diene conjugate content and glutathione reductase and glutathione peroxidase activities in muscles and blood serum. These changes can be related to mobilization of the glutathione reductase/glutathione peroxidase system coupled with intensification of free radical oxidation. In addition, activity of glucose-6-phosphodehydrogenase and NADP-dependent isocitrate dehydrogenase increased, which can be related to increased demand of NADPH for the glutathione reductase/glutathione peroxidase system. The content of reduced glutathione in muscles and blood serum decreased, probably, due to its utilization for ROS neutralization. Glutathione transferase activity decreased in rheumatoid arthritis, which can be related to shortness of reduced glutathione developing during oxidative stress. The observed shifts in parameters of free radical homeostasis in rheumatoid arthritis are probably associated with intensification of free radical oxidation. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a rheumatoid arthritis |2 nationallicence | |
| 690 | 7 | |a free radical oxidation |2 nationallicence | |
| 690 | 7 | |a glutathione antioxidant system |2 nationallicence | |
| 690 | 7 | |a NADPH-generating enzymes |2 nationallicence | |
| 700 | 1 | |a Kryl'skii |D E. |u Department of Medical Biochemistry and Microbiology of the Biology and Soil Faculty, Voronezh State University, Voronezh, Russia |4 aut | |
| 700 | 1 | |a Popova |D T. |u Department of Medical Biochemistry and Microbiology of the Biology and Soil Faculty, Voronezh State University, Voronezh, Russia |4 aut | |
| 700 | 1 | |a Kirilova |D E. |u Voronezh Regional Clinical Diagnostic Center, Voronezh, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 160/1(2015-11-01), 24-27 |x 0007-4888 |q 160:1<24 |1 2015 |2 160 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3089-0 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3089-0 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kryl'skii |D E. |u Department of Medical Biochemistry and Microbiology of the Biology and Soil Faculty, Voronezh State University, Voronezh, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Popova |D T. |u Department of Medical Biochemistry and Microbiology of the Biology and Soil Faculty, Voronezh State University, Voronezh, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kirilova |D E. |u Voronezh Regional Clinical Diagnostic Center, Voronezh, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 160/1(2015-11-01), 24-27 |x 0007-4888 |q 160:1<24 |1 2015 |2 160 |o 10517 | ||