caa a22 4500 605536759 CHVBK 20210128100854.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10517-015-3089-0 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3089-0 Activity of Glutathione Antioxidant System and NADPH-Generating Enzymes in Rats with Experimental Rheumatoid Arthritis [Elektronische Daten] [E. Kryl'skii, T. Popova, E. Kirilova] Induction of rheumatoid arthritis in rats was accompanied by an increase in diene conjugate content and glutathione reductase and glutathione peroxidase activities in muscles and blood serum. These changes can be related to mobilization of the glutathione reductase/glutathione peroxidase system coupled with intensification of free radical oxidation. In addition, activity of glucose-6-phosphodehydrogenase and NADP-dependent isocitrate dehydrogenase increased, which can be related to increased demand of NADPH for the glutathione reductase/glutathione peroxidase system. The content of reduced glutathione in muscles and blood serum decreased, probably, due to its utilization for ROS neutralization. Glutathione transferase activity decreased in rheumatoid arthritis, which can be related to shortness of reduced glutathione developing during oxidative stress. The observed shifts in parameters of free radical homeostasis in rheumatoid arthritis are probably associated with intensification of free radical oxidation. Springer Science+Business Media New York, 2015 rheumatoid arthritis nationallicence free radical oxidation nationallicence glutathione antioxidant system nationallicence NADPH-generating enzymes nationallicence Kryl'skii E. Department of Medical Biochemistry and Microbiology of the Biology and Soil Faculty, Voronezh State University, Voronezh, Russia aut Popova T. Department of Medical Biochemistry and Microbiology of the Biology and Soil Faculty, Voronezh State University, Voronezh, Russia aut Kirilova E. Voronezh Regional Clinical Diagnostic Center, Voronezh, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 24-27 0007-4888 160:1<24 2015 160 10517 https://doi.org/10.1007/s10517-015-3089-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3089-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kryl'skii E. Department of Medical Biochemistry and Microbiology of the Biology and Soil Faculty, Voronezh State University, Voronezh, Russia aut NATIONALLICENCE 700 1- Popova T. Department of Medical Biochemistry and Microbiology of the Biology and Soil Faculty, Voronezh State University, Voronezh, Russia aut NATIONALLICENCE 700 1- Kirilova E. Voronezh Regional Clinical Diagnostic Center, Voronezh, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 24-27 0007-4888 160:1<24 2015 160 10517