Oligopeptides of Chorionic Gonadotropin β-Subunit in Induction of T Cell Differentiation into Treg and Th17
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3101-8 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-3101-8 | ||
| 245 | 0 | 0 | |a Oligopeptides of Chorionic Gonadotropin β-Subunit in Induction of T Cell Differentiation into Treg and Th17 |h [Elektronische Daten] |c [S. Zamorina, S. Shirshev] |
| 520 | 3 | |a The role of oligopeptides of chorionic gonadotropin β-subunit (LQGV, AQGV, and VLPALP) in induction of differentiation into T-regulatory lymphocytes (Treg) and IL-17-producing lymphocytes (Th17) was studied in an in vitro system. Chorionic gonadotropin and oligopeptides promoted CD4+ cell differentiation into functionally active Treg (FOXP3+GITR+ and FOXP3+CTLA-4+), while chorionic gonadotropin and AQGV additionally stimulated IL-10 production by these cells. In parallel, chorionic gonadotropin and oligopeptides prevented CD4+ cell differentiation into Th17 lymphocytes (ROR-gt+IL-17A+) and suppressed IL-17A secretion. Hence, oligopeptides of chorionic gonadotropin β-subunit promoted differentiation of CD4+ cells into Treg and, in parallel, suppress Th17 induction, thus virtually completely reproducing the effects of the hormone, which opens new vista for their use in clinical practice. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a chorionic gonadotropin |2 nationallicence | |
| 690 | 7 | |a regulatory oligopeptides (LQGV, AQGV, and VLPALP) |2 nationallicence | |
| 690 | 7 | |a Th17 |2 nationallicence | |
| 690 | 7 | |a Treg |2 nationallicence | |
| 700 | 1 | |a Zamorina |D S. |u Laboratory of Immunoregulation, Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia |4 aut | |
| 700 | 1 | |a Shirshev |D S. |u Laboratory of Immunoregulation, Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 160/1(2015-11-01), 72-75 |x 0007-4888 |q 160:1<72 |1 2015 |2 160 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3101-8 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3101-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zamorina |D S. |u Laboratory of Immunoregulation, Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shirshev |D S. |u Laboratory of Immunoregulation, Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 160/1(2015-11-01), 72-75 |x 0007-4888 |q 160:1<72 |1 2015 |2 160 |o 10517 | ||