caa a22 4500 605536821 CHVBK 20210128100854.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10517-015-3111-6 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3111-6 Differentiation and Cell-Cell Interactions of Neural Progenitor Cells Transplanted into Intact Adult Brain [Elektronische Daten] [K. Sukhinich, A. Kosykh, M. Aleksandrova] We studied the behavior and cell-cell interactions of embryonic brain cell from GFP-reporter mice after their transplantation into the intact adult brain. Fragments or cell suspensions of fetal neocortical cells at different stages of development were transplanted into the neocortex and striatum of adult recipients. Even in intact brain, the processes of transplanted neurons formed extensive networks in the striatum and neocortical layers I and V-VI. Processes of transplanted cells at different stages of development attained the rostral areas of the frontal cortex and some of them reached the internal capsule. However, the cells transplanted in suspension had lower process growth potency than cells from tissue fragments. Tyrosine hydroxylase fibers penetrated from the recipient brain into grafts at both early and late stages of development. Our experiments demonstrated the formation of extensive reciprocal networks between the transplanted fetal neural cells and recipient brain neurons even in intact brain. Springer Science+Business Media New York, 2015 neurotransplantation nationallicence undifferentiated cells nationallicence GFP mouse nationallicence cell processes nationallicence immunohistochemistry nationallicence Sukhinich K. N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut Kosykh A. N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut Aleksandrova M. N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 115-122 0007-4888 160:1<115 2015 160 10517 https://doi.org/10.1007/s10517-015-3111-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3111-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sukhinich K. N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Kosykh A. N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Aleksandrova M. N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 115-122 0007-4888 160:1<115 2015 160 10517