Role of PI3K, ERK, and p38 Signaling Pathways in the Production of Humoral Erythropoiesis Regulators under Normal Conditions

Verfasser / Beitragende:
[A. Dygai, V. Zhdanov, L. Miroshnichenko, E. Udut, G. Zyuz'kov, T. Khrichkova, E. Simanina, E. Sherstoboev, L. Stavrova, A. Chaikovskii, Ya. Burmina, V. Agafonov, D. Reikhart]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 160/1(2015-11-01), 17-19
Format:
Artikel (online)
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245 0 0 |a Role of PI3K, ERK, and p38 Signaling Pathways in the Production of Humoral Erythropoiesis Regulators under Normal Conditions  |h [Elektronische Daten]  |c [A. Dygai, V. Zhdanov, L. Miroshnichenko, E. Udut, G. Zyuz'kov, T. Khrichkova, E. Simanina, E. Sherstoboev, L. Stavrova, A. Chaikovskii, Ya. Burmina, V. Agafonov, D. Reikhart] 
520 3 |a PI3- and MAP-kinase signaling pathways duplicate and interchange each other in production of agents that determine total erythropoietic activity under conditions of balanced erythropoiesis. The alternative p38-dependent MAP-kinase pathway is the major regulator of erythropoietic activity of adherent bone marrow cells. Blockade of PI3K and p38 signaling pathways stimulated production of erythropoietin by cells that do not produce it constitutively. 
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690 7 |a erythropoietin  |2 nationallicence 
690 7 |a erythropoietic activity  |2 nationallicence 
700 1 |a Dygai  |D A.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Zhdanov  |D V.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Miroshnichenko  |D L.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Udut  |D E.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Zyuz'kov  |D G.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Khrichkova  |D T.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Simanina  |D E.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Sherstoboev  |D E.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Stavrova  |D L.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Chaikovskii  |D A.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Burmina  |D Ya  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Agafonov  |D V.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Reikhart  |D D.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
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