caa a22 4500 605536848 CHVBK 20210128100854.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10517-015-3087-2 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3087-2 Role of PI3K, ERK, and p38 Signaling Pathways in the Production of Humoral Erythropoiesis Regulators under Normal Conditions [Elektronische Daten] [A. Dygai, V. Zhdanov, L. Miroshnichenko, E. Udut, G. Zyuz'kov, T. Khrichkova, E. Simanina, E. Sherstoboev, L. Stavrova, A. Chaikovskii, Ya. Burmina, V. Agafonov, D. Reikhart] PI3- and MAP-kinase signaling pathways duplicate and interchange each other in production of agents that determine total erythropoietic activity under conditions of balanced erythropoiesis. The alternative p38-dependent MAP-kinase pathway is the major regulator of erythropoietic activity of adherent bone marrow cells. Blockade of PI3K and p38 signaling pathways stimulated production of erythropoietin by cells that do not produce it constitutively. Springer Science+Business Media New York, 2015 PI3K nationallicence ERK1/2 nationallicence p38 nationallicence erythropoietin nationallicence erythropoietic activity nationallicence Dygai A. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Zhdanov V. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Miroshnichenko L. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Udut E. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Zyuz'kov G. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Khrichkova T. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Simanina E. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Sherstoboev E. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Stavrova L. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Chaikovskii A. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Burmina Ya E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Agafonov V. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Reikhart D. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 17-19 0007-4888 160:1<17 2015 160 10517 https://doi.org/10.1007/s10517-015-3087-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3087-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dygai A. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Zhdanov V. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Miroshnichenko L. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Udut E. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Zyuz'kov G. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Khrichkova T. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Simanina E. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Sherstoboev E. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Stavrova L. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Chaikovskii A. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Burmina Ya E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Agafonov V. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 700 1- Reikhart D. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 17-19 0007-4888 160:1<17 2015 160 10517