caa a22 4500 605536856 CHVBK 20210128100854.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10517-015-3100-9 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3100-9 Comparison of Pharmacological Potency and Safety of Glutamate Blocker IEM-1913 and Memantine [Elektronische Daten] [V. Gmiro, S. Serdyuk, O. Veselkina] Adamantane-containing glutamate blocker IEM-1913 (1-amino-4-(1-adamantane-amino)-butane dihydrochloride) equals to memantine in antiparkinsonian potency, but surpasses it in anticonvulsive, antidepressant, and analgesic activities. Moreover, its use is less toxic and safer. IEM-1913 produces significant pharmacological effects at a wide concentration diapason (0.03-1.00 mg/kg), while memantine is effective within a narrow range only (15-20 mg/kg). High pharmacological efficacy and low toxicity of IEM-1913 can be explained by the fact that in contrast to monocationic selective NMDA antagonist memantine, the dicationic glutamate blocker IEM-1913 produces a combined block of cerebral NMDA and AMPA receptors. Springer Science+Business Media New York, 2015 NMDA nationallicence AMPA nationallicence IEM-1913 nationallicence memantine nationallicence parkinsonism nationallicence Gmiro V. Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia aut Serdyuk S. Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia aut Veselkina O. Verteks, St. Petersburg, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 68-71 0007-4888 160:1<68 2015 160 10517 https://doi.org/10.1007/s10517-015-3100-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3100-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gmiro V. Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Serdyuk S. Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Veselkina O. Verteks, St. Petersburg, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 68-71 0007-4888 160:1<68 2015 160 10517