caa a22 4500 605536910 CHVBK 20210128100854.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10517-015-3086-3 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3086-3 Methylarginines in Mice with Experimental Atherosclerosis [Elektronische Daten] [M. Gilinsky, R. Sukhovershin, M. Cherkanova] We studied the dynamics of indexes for the system of endogenous regulation of NO bioavailability. The content of NO synthase inhibitors (monomethylarginine and asymmetric dimethylarginine) in the blood of mice was measured after intraperitoneal injections of a nonionic surfactant poloxamer 407 for 2 and 14 weeks. The concentrations of both methylarginines in animals with atherosclerosis due to 14-week administration of poloxamer were much higher than in control specimens. The amount of arginine and symmetric dimethylarginine practically did not differ from the control. Poloxamer-induced model of atherosclerosis is characterized by increased content of NO synthase inhibitors. These changes contribute to the development of endothelial dysfunction and atherosclerosis. Springer Science+Business Media New York, 2015 monomethylarginine nationallicence asymmetric dimethylarginine nationallicence poloxamer 407 nationallicence athero-sclerosis nationallicence Gilinsky M. Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Sukhovershin R. Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Cherkanova M. Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 13-16 0007-4888 160:1<13 2015 160 10517 https://doi.org/10.1007/s10517-015-3086-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3086-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gilinsky M. Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Sukhovershin R. Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Cherkanova M. Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 13-16 0007-4888 160:1<13 2015 160 10517