caa a22 4500 60553697X CHVBK 20210128100855.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10517-015-3083-6 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3083-6 Reconsolidation of Reminder-Induced Amnesia: Role of NMDA and AMPA Glutamate Receptors [Elektronische Daten] [V. Nikitin, S. Kozyrev, S. Solntseva] We studied the role of glutamate receptors and reminder in the mechanisms of amnesia maintenance caused by disruption of conditioned food aversion reconsolidation with an antagonist of NMDA glutamate receptor in snails. At the early stage of amnesia (day 3 after induction), injection or NMDA of AMPA glutamate receptor antagonists prior to reminder (presentation of the conditioned food stimulus) led to memory recovery. Reminder alone or injection of antagonists without reminder or after reminder was ineffective. At the late stage of amnesia (day 10), antagonists/reminder had no effect on amnesia maintenance. It was hypothesized that reminder at the early stage of amnesia led to reactivation and reconsolidation of the molecular processes of amnesia including activation NMDA and AMPA glutamate receptors. Injection of antagonists of these receptors prior to reminder led to disruption of reactivation/reconsolidation of amnesia and recovery of the conditioned food aversion memory. Springer Science+Business Media New York, 2015 Memory nationallicence reconsolidation nationallicence amnesia nationallicence NMDA nationallicence AMPA glutamate receptors nationallicence Nikitin V. P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia aut Kozyrev S. P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia aut Solntseva S. P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 1-5 0007-4888 160:1<1 2015 160 10517 https://doi.org/10.1007/s10517-015-3083-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3083-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nikitin V. P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Kozyrev S. P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Solntseva S. P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 1-5 0007-4888 160:1<1 2015 160 10517