caa a22 4500 605536996 CHVBK 20210128100855.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10517-015-3119-y doi (NATIONALLICENCE)springer-10.1007/s10517-015-3119-y Therapy of Chronic Cardiosclerosis in WAG Rats Using Cultures of Cardiovascular Cells Enriched with Cardiac Stem Cell [Elektronische Daten] [E. Chepeleva, S. Pavlova, A. Malakhova, E. Milevskaya, Ya. Rusakova, N. Podkhvatilina, D. Sergeevichev, E. Pokushalov, A. Karaskov, G. Sukhikh, S. Zakiyan] We developed a protocol for preparing cardiac cell culture from rat heart enriched with regional stem cells based on clonogenic properties and proliferation in culture in a medium with low serum content. Experiments on WAG rats with experimental ischemic myocardial damage showed that implantation of autologous regional stem cells into the left ventricle reduced the volume of cicatricial tissue, promoted angiogenesis in the damaged zone, and prevented the risk of heart failure development. Springer Science+Business Media New York, 2015 cardiac stem cells nationallicence cell therapy nationallicence myocardial infarction nationallicence Chepeleva E. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Moscow, Russia aut Pavlova S. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Moscow, Russia aut Malakhova A. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Moscow, Russia aut Milevskaya E. E. N. Meshalkin Research Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Moscow, Russia aut Rusakova Ya E. N. Meshalkin Research Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Moscow, Russia aut Podkhvatilina N. E. N. Meshalkin Research Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Moscow, Russia aut Sergeevichev D. E. N. Meshalkin Research Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Moscow, Russia aut Pokushalov E. E. N. Meshalkin Research Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Moscow, Russia aut Karaskov A. E. N. Meshalkin Research Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Moscow, Russia aut Sukhikh G. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia aut Zakiyan S. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 165-173 0007-4888 160:1<165 2015 160 10517 https://doi.org/10.1007/s10517-015-3119-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3119-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chepeleva E. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Pavlova S. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Malakhova A. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Milevskaya E. E. N. Meshalkin Research Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Rusakova Ya E. N. Meshalkin Research Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Podkhvatilina N. E. N. Meshalkin Research Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Sergeevichev D. E. N. Meshalkin Research Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Pokushalov E. E. N. Meshalkin Research Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Karaskov A. E. N. Meshalkin Research Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Sukhikh G. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Zakiyan S. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 165-173 0007-4888 160:1<165 2015 160 10517