Study of Subchronic Toxicity of Relatox on Sexually Immature Animals

Verfasser / Beitragende:
[A. Churin, T. Fomina, L. Ermolaeva, T. Vetoshkina, T. Dubskaya, T. Lamzina, E. Fedorova, O. Neupokoeva, A. Nikiforova]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 160/1(2015-11-01), 53-56
Format:
Artikel (online)
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245 0 0 |a Study of Subchronic Toxicity of Relatox on Sexually Immature Animals  |h [Elektronische Daten]  |c [A. Churin, T. Fomina, L. Ermolaeva, T. Vetoshkina, T. Dubskaya, T. Lamzina, E. Fedorova, O. Neupokoeva, A. Nikiforova] 
520 3 |a Intramuscular injections of Relatox in therapeutic and toxic doses to young outbred laboratory rats for 14 days caused no changes in the peripheral blood and bone marrow parameters, serum biochemical parameters, and morphology of the major viscera. In the toxic dose, the drug caused local irritation (inflammation, atrophy, and sclerosis in muscle tissue). Regeneration processes started in muscle tissue 7 days after Relatox withdrawal. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a Relatox  |2 nationallicence 
690 7 |a subchronic toxicity  |2 nationallicence 
690 7 |a young rats  |2 nationallicence 
690 7 |a botulinum toxin A  |2 nationallicence 
690 7 |a preclinical studies  |2 nationallicence 
700 1 |a Churin  |D A.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Fomina  |D T.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Ermolaeva  |D L.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Vetoshkina  |D T.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Dubskaya  |D T.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Lamzina  |D T.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Fedorova  |D E.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Neupokoeva  |D O.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
700 1 |a Nikiforova  |D A.  |u Microgen Research-and-Production Center for Medical and Immunobiological Drugs, Ministry of Health of the Russian Federation, Moscow, Russia  |4 aut 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Fomina  |D T.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Ermolaeva  |D L.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Vetoshkina  |D T.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Dubskaya  |D T.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Lamzina  |D T.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Fedorova  |D E.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Neupokoeva  |D O.  |u E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Nikiforova  |D A.  |u Microgen Research-and-Production Center for Medical and Immunobiological Drugs, Ministry of Health of the Russian Federation, Moscow, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 160/1(2015-11-01), 53-56  |x 0007-4888  |q 160:1<53  |1 2015  |2 160  |o 10517