caa a22 4500 605537062 CHVBK 20210128100855.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10517-015-3088-1 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3088-1 State of Stress-Marker Organs in Rats with Various Behavioral Characteristics during Repeated Stress Exposures [Elektronische Daten] [S. Pertsov, O. Grigorchuk, E. Koplik, A. Abramova, N. Chekmareva, V. Chekhlov] Changes in the relative weight of stress-marker organs in rats with various behavioral patterns in the open-field test were studied after repeated stress exposures on the model of daily 4-h immobilization over 8 days. Involution of the thymus and spleen in behaviorally passive specimens was found after single stress, as well as under conditions of 3- and 8-fold immobilizations. The weight of these organs in active animals remained practically unchanged after acute stress, but decreased on day 3 and particularly on day 8 of repeated stress exposures. As differentiated from passive rats (open-field test), behaviorally active specimens were characterized by hypertrophy of the adrenal glands after single and 3-fold stress procedures. Our results complement the data on individual features of the peripheral and central mechanisms for the stress response in mammals. These data illustrate the importance of individual approach to studying systemic organization of physiological functions under normal conditions and during negative emotiogenic exposures. Springer Science+Business Media New York, 2015 repeated stress exposures nationallicence stress-marker organs nationallicence behaviorally passive and active rats nationallicence Pertsov S. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut Grigorchuk O. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut Koplik E. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut Abramova A. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut Chekmareva N. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut Chekhlov V. A. I. Evdokimov Moscow State Medical and Dental University, Ministry of Health of the Russian Federation, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 20-23 0007-4888 160:1<20 2015 160 10517 https://doi.org/10.1007/s10517-015-3088-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3088-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pertsov S. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut NATIONALLICENCE 700 1- Grigorchuk O. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut NATIONALLICENCE 700 1- Koplik E. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut NATIONALLICENCE 700 1- Abramova A. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut NATIONALLICENCE 700 1- Chekmareva N. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut NATIONALLICENCE 700 1- Chekhlov V. A. I. Evdokimov Moscow State Medical and Dental University, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 20-23 0007-4888 160:1<20 2015 160 10517