caa a22 4500 605537070 CHVBK 20210128100855.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10517-015-3107-2 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3107-2 Effect of Combined Stress on Morphological Changes and Expression of NO Synthases in Rat Ventral Hippocampus [Elektronische Daten] [A. Smirnov, I. Tyurenkov, M. Shmidt, M. Ekova, D. Mednikov, D. Borodin] Adult rats were subjected to 7-day combined stress with stochastic changes of stressors of different modalities (noise, vibration, pulsating bright light) along with mobility restriction and elevated temperature in the chamber during stress exposures (daily 30-min sessions). Circulatory disorders, inhibition of endothelial NO-synthase expression in endothelial cells of the microcirculatory bed, perivascular edema, pronounced degenerative changes, and enhanced expression of inducible NO synthase in CA3 pyramidal neurons in the ventral hippocampus of stressed 12-month-old rats were observed. These findings can attest to the involvement NOdependent mechanisms and different contribution of NO synthase isoforms into the formation of hippocampal neuronal damage. Springer Science+Business Media New York, 2015 hippocampus nationallicence rat nationallicence stress nationallicence inducible NO synthase nationallicence endothelial NO synthase nationallicence Smirnov A. Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia aut Tyurenkov I. Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia aut Shmidt M. Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia aut Ekova M. Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia aut Mednikov D. Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia aut Borodin D. Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 96-99 0007-4888 160:1<96 2015 160 10517 https://doi.org/10.1007/s10517-015-3107-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3107-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Smirnov A. Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia aut NATIONALLICENCE 700 1- Tyurenkov I. Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia aut NATIONALLICENCE 700 1- Shmidt M. Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia aut NATIONALLICENCE 700 1- Ekova M. Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia aut NATIONALLICENCE 700 1- Mednikov D. Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia aut NATIONALLICENCE 700 1- Borodin D. Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/1(2015-11-01), 96-99 0007-4888 160:1<96 2015 160 10517