caa a22 4500 605537100 CHVBK 20210128100855.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10517-015-3136-x doi (NATIONALLICENCE)springer-10.1007/s10517-015-3136-x Mechanisms of Disruptive Action of Dichlorodiphenyltrichloroethane (DDT) on the Function of Thyroid Follicular Epitheliocytes [Elektronische Daten] [N. Yaglova, V. Yaglov] The mechanism of disruptive action of dichlorodiphenyltrichloroethane (DDT) on the function of thyroid follicular epitheliocytes was examined in mature male Wistar rats administered with a daily dose of DDT (2 μg/kg) for 6 or 10 weeks. In 6 weeks, the serum level of Na+/I - symporter responsible for the transport of iodides into follicular thyrocytes decreased, while serum concentration of thyroperoxidase increased. In 10 weeks, both the number of follicles in the thyroid gland and serum level of Na+/I - symporter increased. In circulating blood, the concentrations of thyroglobulin as well as α and β receptors of the thyroid hormones did not change. DDT down-regulated the iodine-accumulated function of follicular thyrocytes by suppressing Na+/I - symporter synthesis. Recovery of Na+/I - symporter production resulted from up-regulation of the proliferative processes in thyroid gland. Springer Science+Business Media New York, 2015 dichlorodiphenyltrichloroethane nationallicence endocrine disruptor nationallicence thyroid gland nationallicence Yaglova N. Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia aut Yaglov V. Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 231-233 0007-4888 160:2<231 2015 160 10517 https://doi.org/10.1007/s10517-015-3136-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3136-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yaglova N. Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 700 1- Yaglov V. Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 231-233 0007-4888 160:2<231 2015 160 10517