caa a22 4500 605537127 CHVBK 20210128100855.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10517-015-3125-0 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3125-0 Activity of Heme Synthesis Enzymes in the Bone Marrow and Liver of August and Wistar Rats During the Neonatal Period and After Acute Postnatal Hypoxia [Elektronische Daten] [S. Kolesnikov, A. Popova, L. Krupitskaya, A. Sinitskii, L. Kolesnikova] Activity of heme synthesis enzymes in newborn August and Wistar rats was studied after acute hypoxic hypoxia. Daily production of erythrocytes and activities of aminolevulinate synthase, aminolevulinate dehydratase, and heme synthetase were measured in the bone marrow (15-30 min after birth and on days 1 and 3 of life) and liver (day 3 after birth). Hypoxia was followed by a decrease in activity of heme synthesis enzymes in the liver (especially in August rats) and reduction of the daily erythrocyte production (especially in Wistar rats). Our results suggest that the response of heme synthesis enzymes to hypoxic exposure in newborn rats is genetically determined. The observed changes are more pronounced in Wistar rats. Springer Science+Business Media New York, 2015 heme synthesis enzymes nationallicence acute hypoxia nationallicence neonatal period nationallicence August and Wistar rats nationallicence Kolesnikov S. Research Center for Problems of Family Health and Human Reproduction, Irkutsk, Russia aut Popova A. Municipal Clinical Hospital No. 6, Moscow, Russia aut Krupitskaya L. South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut Sinitskii A. South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut Kolesnikova L. Research Center for Problems of Family Health and Human Reproduction, Irkutsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 193-195 0007-4888 160:2<193 2015 160 10517 https://doi.org/10.1007/s10517-015-3125-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3125-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kolesnikov S. Research Center for Problems of Family Health and Human Reproduction, Irkutsk, Russia aut NATIONALLICENCE 700 1- Popova A. Municipal Clinical Hospital No. 6, Moscow, Russia aut NATIONALLICENCE 700 1- Krupitskaya L. South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Sinitskii A. South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Kolesnikova L. Research Center for Problems of Family Health and Human Reproduction, Irkutsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 193-195 0007-4888 160:2<193 2015 160 10517