caa a22 4500 605537143 CHVBK 20210128100856.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10517-015-3138-8 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3138-8 Analysis of Populations of Memory T-Helper Cells Expressing CXCR3 and CCR6 Chemokine Receptors in Peripheral Blood of Patients with Chronic Viral Hepatitis C [Elektronische Daten] [D. Elezov, I. Kudryavtsev, N. Arsent'ev, V. Basin, E. Esaulenko, A. Semenov, A. Totolyan] Flow cytometry was employed to examine the content of major populations of memory T helper cells and expression of chemokine receptors CXCR3 and CCR6 on their surface in peripheral blood drawn from virtually healthy people and the patients with chronic viral hepatitis C. The following combination of monoclonal antibodies had been used: CD62LFITC/CD45RA-PE/CD3-ECD/CCR6-PC7/CXCR3-APC/CD4-APC-Cy7. In comparison with control group, the patients with chronic hepatitis C had a smaller number of populations of naïve CD4+ T cells and central memory CD4+ T cells but a greater number of terminally differentiated effector memory CD4+ T cells and effector memory CD4+ T cells. No differences were revealed between CD4+ T cell populations of both groups in expression of CXCR3 and CCR6 receptors. Springer Science+Business Media New York, 2015 hepatitis C nationallicence memory cells nationallicence CXCR3 nationallicence CCR6 nationallicence CD62L nationallicence Elezov D. Department of Immunology and Seroepidemiology, Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia aut Kudryavtsev I. Department of Immunology, Research Institute of Experimental Medicine, North-Western Division of Russian Academy of Medical Sciences, St. Petersburg, Russia aut Arsent'ev N. Department of Immunology and Seroepidemiology, Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia aut Basin V. Department of Epidemiology in Infectious Diseases in Adults, St. Petersburg State Pediatric Medical University, St. Petersburg, Russia aut Esaulenko E. Department of Epidemiology in Infectious Diseases in Adults, St. Petersburg State Pediatric Medical University, St. Petersburg, Russia aut Semenov A. Department of Immunology and Seroepidemiology, Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia aut Totolyan A. Department of Immunology and Seroepidemiology, Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 238-242 0007-4888 160:2<238 2015 160 10517 https://doi.org/10.1007/s10517-015-3138-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3138-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Elezov D. Department of Immunology and Seroepidemiology, Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Kudryavtsev I. Department of Immunology, Research Institute of Experimental Medicine, North-Western Division of Russian Academy of Medical Sciences, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Arsent'ev N. Department of Immunology and Seroepidemiology, Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Basin V. Department of Epidemiology in Infectious Diseases in Adults, St. Petersburg State Pediatric Medical University, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Esaulenko E. Department of Epidemiology in Infectious Diseases in Adults, St. Petersburg State Pediatric Medical University, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Semenov A. Department of Immunology and Seroepidemiology, Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Totolyan A. Department of Immunology and Seroepidemiology, Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 238-242 0007-4888 160:2<238 2015 160 10517