Serum Glutathione in Patients with Schizophrenia in Dynamics of Antipsychotic Therapy

Verfasser / Beitragende:
[S. Ivanova, L. Smirnova, Yu. Shchigoreva, A. Semke, N. Bokhan]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 160/2(2015-12-01), 283-285
Format:
Artikel (online)
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024 7 0 |a 10.1007/s10517-015-3151-y  |2 doi 
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245 0 0 |a Serum Glutathione in Patients with Schizophrenia in Dynamics of Antipsychotic Therapy  |h [Elektronische Daten]  |c [S. Ivanova, L. Smirnova, Yu. Shchigoreva, A. Semke, N. Bokhan] 
520 3 |a Serum concentrations of oxidized and reduced glutathione were measured in 73 patients with schizophrenia at admission and in dynamics of therapy with traditional and atypical antipsychotic drugs. The level of reduced glutathione in patients with schizophrenia with manifest clinical symptoms was lower than in normal subjects. Atypical neuroleptics produced virtually no effects on the glutathione system, while therapy with typical antipsychotics led to further decrease in the levels of reduced glutathione, thus aggravating the imbalance of metabolic processes typical of schizophrenia. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a schizophrenia  |2 nationallicence 
690 7 |a reduced glutathione  |2 nationallicence 
690 7 |a antipsychotic drugs  |2 nationallicence 
700 1 |a Ivanova  |D S.  |u Research Institute of Mental Health, Tomsk, Russia  |4 aut 
700 1 |a Smirnova  |D L.  |u Research Institute of Mental Health, Tomsk, Russia  |4 aut 
700 1 |a Shchigoreva  |D Yu  |u Research Institute of Mental Health, Tomsk, Russia  |4 aut 
700 1 |a Semke  |D A.  |u Research Institute of Mental Health, Tomsk, Russia  |4 aut 
700 1 |a Bokhan  |D N.  |u Research Institute of Mental Health, Tomsk, Russia  |4 aut 
773 0 |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 160/2(2015-12-01), 283-285  |x 0007-4888  |q 160:2<283  |1 2015  |2 160  |o 10517 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Ivanova  |D S.  |u Research Institute of Mental Health, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Smirnova  |D L.  |u Research Institute of Mental Health, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Shchigoreva  |D Yu  |u Research Institute of Mental Health, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Semke  |D A.  |u Research Institute of Mental Health, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Bokhan  |D N.  |u Research Institute of Mental Health, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 160/2(2015-12-01), 283-285  |x 0007-4888  |q 160:2<283  |1 2015  |2 160  |o 10517