Toxicity and Antiviral Activity of the Extracts of Submerged Mycelium of Nematophagous Duddingtonia flagrans Fungus in Vero Cell Culture
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3140-1 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-3140-1 | ||
| 245 | 0 | 0 | |a Toxicity and Antiviral Activity of the Extracts of Submerged Mycelium of Nematophagous Duddingtonia flagrans Fungus in Vero Cell Culture |h [Elektronische Daten] |c [Zh. Ibragimova, G. Anan'ko, N. Kostina, T. Teplyakova, N. Mazurkova] |
| 520 | 3 | |a We studied toxicity and antiviral activity of aqueous and ethanol extracts of bioactive substances from the biomass of nematophagous fungus Duddingtonia flagrans prepared by submerged culturing of the mycelium. It is found that both extracts were characterized by low toxicity for cultured Vero cells and inhibited reproduction of DNA-viruses in this cell line. Ethanol extract of the fungus exhibited higher in vitro antiviral activity against Herpes simplex virus type 2, ectromelia virus, and vaccinia virus than water extract, which can be due to higher content of proteins, polysaccharides, flavonols, catechins, or carotenes or more effective their combination. The extracts of cultured mycelium of Duddingtonia flagrans fungus containing a complex of bioactive substances can be used for creation of broad-spectrum antiviral drugs against DNA-viruses. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a nematophagous fungus extract |2 nationallicence | |
| 690 | 7 | |a orthopoxviruses |2 nationallicence | |
| 690 | 7 | |a herpes simplex virus |2 nationallicence | |
| 700 | 1 | |a Ibragimova |D Zh |u Vector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk Region, Russia |4 aut | |
| 700 | 1 | |a Anan'ko |D G. |u Vector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk Region, Russia |4 aut | |
| 700 | 1 | |a Kostina |D N. |u Vector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk Region, Russia |4 aut | |
| 700 | 1 | |a Teplyakova |D T. |u Vector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk Region, Russia |4 aut | |
| 700 | 1 | |a Mazurkova |D N. |u Vector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk Region, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 160/2(2015-12-01), 246-248 |x 0007-4888 |q 160:2<246 |1 2015 |2 160 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3140-1 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3140-1 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ibragimova |D Zh |u Vector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk Region, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Anan'ko |D G. |u Vector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk Region, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kostina |D N. |u Vector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk Region, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Teplyakova |D T. |u Vector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk Region, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mazurkova |D N. |u Vector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk Region, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 160/2(2015-12-01), 246-248 |x 0007-4888 |q 160:2<246 |1 2015 |2 160 |o 10517 | ||