caa a22 4500 605537224 CHVBK 20210128100856.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10517-015-3121-4 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3121-4 Behavioral Indexes of Thermal Nociceptive Sensitivity in Rats after Melatonin Administration [Elektronische Daten] [B. Zhuravlev, E. Murtazina, S. Pertsov] We studied the effect of melatonin (10 mg/kg intraperitoneally) on behavioral indexes reflecting changes in nociceptive sensitivity of rats in response to thermal stimulation in the hot plate test. Administration of melatonin to animals suppressed the perceptual component of nociception, which was manifested in an increase in the perception threshold of noxious thermal stimulus. In the follow-up period, exogenous melatonin contributed to a decrease in the latency of avoidance reactions and enhanced the behavior of escaping the thermal nociceptive stimulation. Our results suggest that the involvement of melatonin in goal-directed behavior of mammals during nociceptive treatment is related to an increase in orientation and exploratory activity, facilitation of memory storage, and improvement of memory retrieval for environmental signals, action program, and reinforcing effect of avoiding the painful stimulus. Springer Science+Business Media New York, 2015 rats nationallicence nociception nationallicence temperature sensitivity nationallicence behavior nationallicence melatonin nationallicence Zhuravlev B. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut Murtazina E. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut Pertsov S. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 179-182 0007-4888 160:2<179 2015 160 10517 https://doi.org/10.1007/s10517-015-3121-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3121-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhuravlev B. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut NATIONALLICENCE 700 1- Murtazina E. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut NATIONALLICENCE 700 1- Pertsov S. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 179-182 0007-4888 160:2<179 2015 160 10517