caa a22 4500 605537259 CHVBK 20210128100856.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10517-015-3128-x doi (NATIONALLICENCE)springer-10.1007/s10517-015-3128-x Antioxidant Effect of Erythropoietin during Experimental Chronic Renal Failure [Elektronische Daten] [M. Osikov, L. Telesheva, Yu. Ageev] The effects of erythropoietin (Epokrin, 900 U/kg) on the parameters of free radical oxidation in the plasma and lymphocytes of peripheral blood were studied in rats with chronic renal failure. We observed accumulation of primary (diene conjugates) and secondary (ketodienes, and conjugated trienes) LPO products in the heptane and isopropanol fractions of blood plasma and a decrease in superoxide dismutase and catalase activities in blood plasma. In lymphocytes, the concentration of primary, secondary and end-products (Schiff bases) of LPO increased in the isopropanol fraction of lipid extract. Treatment with erythropoietin was followed by a decrease in the level of primary and end-products of LPO in the isopropanol fraction of lipid extract of the plasma and lymphocytes and an increase in of superoxide dismutase and catalase activities in the plasma. The content of primary LPO products in the isopropanol fraction of the plasma progressively decreased with increasing superoxide dismutase and catalase activities in the plasma. Springer Science+Business Media New York, 2015 erythropoietin nationallicence LPO products nationallicence catalase nationallicence superoxide dismutase: chronic renal Failure nationallicence Osikov M. South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut Telesheva L. South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut Ageev Yu South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 202-204 0007-4888 160:2<202 2015 160 10517 https://doi.org/10.1007/s10517-015-3128-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3128-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Osikov M. South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Telesheva L. South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut NATIONALLICENCE 700 1- Ageev Yu South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 202-204 0007-4888 160:2<202 2015 160 10517