Chemokine Receptors CXCR3 and CCR6 and Their Ligands in the Liver and Blood of Patients with Chronic Hepatitis C
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3142-z |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-3142-z | ||
| 245 | 0 | 0 | |a Chemokine Receptors CXCR3 and CCR6 and Their Ligands in the Liver and Blood of Patients with Chronic Hepatitis C |h [Elektronische Daten] |c [N. Arsent'eva, A. Semenov, N. Lyubimova, Yu. Ostankov, D. Elezo, I. Kudryavtsev, V. Basina, E. Esaulenko, K. Kozlov, K. Zhdanov, A. Totolyan] |
| 520 | 3 | |a We performed a comprehensive analysis of CCR6 and CXCR3 chemokine receptors and their ligands CCL20/MIP-3α, CXCL9/MIG, CXCL10/IP-10, and CXCL11/ITAC in the liver and blood of patients with chronic hepatitis C at different stages of the disease. TaqMan PCR was used to determine mRNA gene expression of chemokines and their receptors in liver specimens, xMAP multiplex analysis was performed to estimate the concentration of chemokines in blood plasma, and fl ow cytofluorometry was used to evaluate CCR6 and CXCR3 expression on peripheral blood lymphocyte populations. In the liver of patients with hepatitis C, mRNA expression of CXCL10, CCR6, and CXCR3 genes increases with fibrosis progression in the liver tissue. In the plasma, concentrations of all studied chemokines increased depending on the stage of liver fibrosis, CCR6 and CXCR3 expression was changed in various lymphocyte populations. Thus, chemokines are involved in the immunopathogenesis and fibrogenesis in chronic viral hepatitis C. The results suggest using these chemokines in the diagnosis and prognosis of the disease. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a viral hepatitis C |2 nationallicence | |
| 690 | 7 | |a chemokines |2 nationallicence | |
| 690 | 7 | |a fibrogenesis |2 nationallicence | |
| 690 | 7 | |a immunopathogenesis |2 nationallicence | |
| 690 | 7 | |a biomarkers |2 nationallicence | |
| 700 | 1 | |a Arsent'eva |D N. |u Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Semenov |D A. |u Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Lyubimova |D N. |u Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Ostankov |D Yu |u Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Elezo |D D. |u Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Kudryavtsev |D I. |u Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Basina |D V. |u St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Esaulenko |D E. |u St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Kozlov |D K. |u S. M. Kirov Military Medical Academy, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Zhdanov |D K. |u S. M. Kirov Military Medical Academy, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Totolyan |D A. |u Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 160/2(2015-12-01), 252-255 |x 0007-4888 |q 160:2<252 |1 2015 |2 160 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3142-z |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3142-z |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Arsent'eva |D N. |u Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Semenov |D A. |u Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lyubimova |D N. |u Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ostankov |D Yu |u Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Elezo |D D. |u Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kudryavtsev |D I. |u Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Basina |D V. |u St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Esaulenko |D E. |u St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kozlov |D K. |u S. M. Kirov Military Medical Academy, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhdanov |D K. |u S. M. Kirov Military Medical Academy, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Totolyan |D A. |u Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 160/2(2015-12-01), 252-255 |x 0007-4888 |q 160:2<252 |1 2015 |2 160 |o 10517 | ||