caa a22 4500 605537283 CHVBK 20210128100856.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10517-015-3130-3 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3130-3 pH-Dependent Changes in the Mechanisms of Transport of Chlorine e6 and Its Derivatives in the Blood [Elektronische Daten] [I. Khludeev, L. Kozyr', T. Zorina, V. Zorin] We studied the effects of medium pH on steady-state distribution of chlorine e6 and its derivatives between the main transport proteins of human blood plasma. The decrease in medium pH from weakly alkaline (pH 7.4) to acid (pH 5.0) was followed by an increase in relative affinity of chlorines to lipoproteins and reduced their affinity to serum albumin. pH-Dependent changes in the parameters of distribution of photosensitizers between the plasma and blood cells was revealed. We discussed the role of charge and polarity degree of photosensitizer molecule in the mechanism of binding to serum albumin. A possible role of changes in hydrogen ion activity in the processes of selective accumulation of chlorines by tumor cells is discussed. Springer Science+Business Media New York, 2015 chlorine e 6 nationallicence blood serum nationallicence albumin nationallicence lipoproteins nationallicence pH of medium nationallicence Khludeev I. Research Laboratory of Biophysics and Biotechnology, Department of Biophysics, Physical Faculty, Belorussian State University, Minsk, Republic of Belarus aut Kozyr' L. Department of Physics and Mathematics, Pediatric Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia aut Zorina T. Research Laboratory of Biophysics and Biotechnology, Department of Biophysics, Physical Faculty, Belorussian State University, Minsk, Republic of Belarus aut Zorin V. Research Laboratory of Biophysics and Biotechnology, Department of Biophysics, Physical Faculty, Belorussian State University, Minsk, Republic of Belarus aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 208-212 0007-4888 160:2<208 2015 160 10517 https://doi.org/10.1007/s10517-015-3130-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3130-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Khludeev I. Research Laboratory of Biophysics and Biotechnology, Department of Biophysics, Physical Faculty, Belorussian State University, Minsk, Republic of Belarus aut NATIONALLICENCE 700 1- Kozyr' L. Department of Physics and Mathematics, Pediatric Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Zorina T. Research Laboratory of Biophysics and Biotechnology, Department of Biophysics, Physical Faculty, Belorussian State University, Minsk, Republic of Belarus aut NATIONALLICENCE 700 1- Zorin V. Research Laboratory of Biophysics and Biotechnology, Department of Biophysics, Physical Faculty, Belorussian State University, Minsk, Republic of Belarus aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 208-212 0007-4888 160:2<208 2015 160 10517