caa a22 4500 605537291 CHVBK 20210128100856.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10517-015-3141-0 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3141-0 Study of Cytokine Profile of Cultured "Early” and "Late” Endothelial Progenitor Cells in Peripheral Blood of Chronic Heart Failure Patients after Mobilization Course with Granulocyte Colony-Stimulating Factor [Elektronische Daten] [N. Bondarenko, O. Poveshchenko, A. Lykov, I. Kim, M. Surovtseva, A. Poveshchenko, E. Pokushalov, A. Romanov, A. Karas'kov, V. Konenkov] The effect of cell culturing protocol with various adhesion proteins and different culture time on the profile of cytokine and growth factors produced by endothelial progenitor cells harvested after mobilization with granulocyte colony-stimulating factor was examined in patients with chronic heart failure. The endothelial progenitor cells cultured on fibronectin or gelatin produced a broad and overall similar spectrum of cytokines and growth factors, the levels of which depended on the culture time. On culture day 16, the cells grown on fibronectin diminished the production of cytokines and growth factors (IL-10, IL-18, IL-8, erythropoietin, and VEGF), while the cells grown on gelatin down-regulated the synthesis of TNF-α, IL-8, and erythropoietin, although they up-regulated the production of IL-10, IL-18, and VEGF. Springer Science+Business Media New York, 2015 endothelial progenitor cells nationallicence cytokines nationallicence growth factors nationallicence chronic heart failure nationallicence Bondarenko N. Research Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Poveshchenko O. Research Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Lykov A. Research Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Kim I. Research Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Surovtseva M. Research Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Poveshchenko A. Research Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Pokushalov E. E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut Romanov A. E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut Karas'kov A. E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut Konenkov V. Research Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 249-251 0007-4888 160:2<249 2015 160 10517 https://doi.org/10.1007/s10517-015-3141-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3141-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bondarenko N. Research Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Poveshchenko O. Research Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Lykov A. Research Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Kim I. Research Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Surovtseva M. Research Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Poveshchenko A. Research Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Pokushalov E. E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Romanov A. E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Karas'kov A. E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Konenkov V. Research Institute of Experimental and Clinical Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 249-251 0007-4888 160:2<249 2015 160 10517