Role of Interleukin-10 Gene Promoter Region Polymorphism in the Development of Chronic Lymphoid Leukemia
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| 024 | 7 | 0 | |a 10.1007/s10517-015-3148-6 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-3148-6 | ||
| 245 | 0 | 0 | |a Role of Interleukin-10 Gene Promoter Region Polymorphism in the Development of Chronic Lymphoid Leukemia |h [Elektronische Daten] |c [V. Ovsepyan, A. Gabdulkhakova, A. Shubenkiva, E. Zotina] |
| 520 | 3 | |a Relationship between interleukin-10 (IL-10) gene G-1082A (rs1800896) polymorphism and the risk of development and stages of chronic lymphoid leukemia is studied in ethnic Russian residents of the Kirov region of Russia. Associations of allele -1082A and genotypes (-1082AA/-1082AG) with the risk of chronic lymphoid leukemia are detected (OR=1.39, 95%CI=1.09-1.78 and OR=1.66, 95%CI=1.09-2.54, respectively). In addition, association of 1082AA genotype with late stages of the disease by the moment of diagnosis is detected. These data indicate that IL-10 polymorphism G-1082A may be involved in the pathogenesis of chronic lymphoid leukemia. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a chronic lymphoid leukemia |2 nationallicence | |
| 690 | 7 | |a interleukin-10 |2 nationallicence | |
| 690 | 7 | |a single nucleotide polymorphism |2 nationallicence | |
| 700 | 1 | |a Ovsepyan |D V. |u Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia |4 aut | |
| 700 | 1 | |a Gabdulkhakova |D A. |u Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia |4 aut | |
| 700 | 1 | |a Shubenkiva |D A. |u Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia |4 aut | |
| 700 | 1 | |a Zotina |D E. |u Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 160/2(2015-12-01), 275-277 |x 0007-4888 |q 160:2<275 |1 2015 |2 160 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3148-6 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3148-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ovsepyan |D V. |u Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gabdulkhakova |D A. |u Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shubenkiva |D A. |u Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zotina |D E. |u Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 160/2(2015-12-01), 275-277 |x 0007-4888 |q 160:2<275 |1 2015 |2 160 |o 10517 | ||