caa a22 4500 605537305 CHVBK 20210128100856.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10517-015-3148-6 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3148-6 Role of Interleukin-10 Gene Promoter Region Polymorphism in the Development of Chronic Lymphoid Leukemia [Elektronische Daten] [V. Ovsepyan, A. Gabdulkhakova, A. Shubenkiva, E. Zotina] Relationship between interleukin-10 (IL-10) gene G-1082A (rs1800896) polymorphism and the risk of development and stages of chronic lymphoid leukemia is studied in ethnic Russian residents of the Kirov region of Russia. Associations of allele -1082A and genotypes (-1082AA/-1082AG) with the risk of chronic lymphoid leukemia are detected (OR=1.39, 95%CI=1.09-1.78 and OR=1.66, 95%CI=1.09-2.54, respectively). In addition, association of 1082AA genotype with late stages of the disease by the moment of diagnosis is detected. These data indicate that IL-10 polymorphism G-1082A may be involved in the pathogenesis of chronic lymphoid leukemia. Springer Science+Business Media New York, 2015 chronic lymphoid leukemia nationallicence interleukin-10 nationallicence single nucleotide polymorphism nationallicence Ovsepyan V. Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia aut Gabdulkhakova A. Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia aut Shubenkiva A. Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia aut Zotina E. Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 275-277 0007-4888 160:2<275 2015 160 10517 https://doi.org/10.1007/s10517-015-3148-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3148-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ovsepyan V. Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia aut NATIONALLICENCE 700 1- Gabdulkhakova A. Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia aut NATIONALLICENCE 700 1- Shubenkiva A. Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia aut NATIONALLICENCE 700 1- Zotina E. Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 275-277 0007-4888 160:2<275 2015 160 10517