The Key Proteins of Dopaminergic Neurotransmission of Human Peripheral Blood Lymphocytes: Changed mRNA Level in Alcohol Dependence Syndrome
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 605537313 | ||
| 003 | CHVBK | ||
| 005 | 20210128100856.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20151201xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10517-015-3147-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-3147-7 | ||
| 245 | 0 | 4 | |a The Key Proteins of Dopaminergic Neurotransmission of Human Peripheral Blood Lymphocytes: Changed mRNA Level in Alcohol Dependence Syndrome |h [Elektronische Daten] |c [A. Taraskina, M. Grunina, A. Zabotina, F. Nasyrova, M. Ivanov, E. Krupitsky, A. Schwartzman] |
| 520 | 3 | |a The expression of dopamine receptor (DRD), Nurr1 transcription factor (NR4A2), and α-sinucleine (SNCA) genes in peripheral blood lymphocytes is evaluated. The results indicate that alcohol dependence is associated with high expression of SNCA and DRD4 (signifi cantly higher than in the control group) and is not associated with changes in the work of NR4A2 and DRD3 genes. The levels of DRD3 and DRD4 mRNA form a positive linear correlation (p≤0.05). The expression of SNCA and DRD4 genes can serve as an important peripheral marker of alcohol dependence development, which is essential for antipsychotic therapy. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a dopaminergic neurotransmission proteins |2 nationallicence | |
| 690 | 7 | |a gene expression |2 nationallicence | |
| 690 | 7 | |a real time quantitative polymerase chain reaction |2 nationallicence | |
| 690 | 7 | |a peripheral blood lymphocytes |2 nationallicence | |
| 690 | 7 | |a alcohol dependence syndrome |2 nationallicence | |
| 700 | 1 | |a Taraskina |D A. |u B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia |4 aut | |
| 700 | 1 | |a Grunina |D M. |u B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia |4 aut | |
| 700 | 1 | |a Zabotina |D A. |u B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia |4 aut | |
| 700 | 1 | |a Nasyrova |D F. |u V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Ivanov |D M. |u V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Krupitsky |D E. |u V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia |4 aut | |
| 700 | 1 | |a Schwartzman |D A. |u B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 160/2(2015-12-01), 271-274 |x 0007-4888 |q 160:2<271 |1 2015 |2 160 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-3147-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-3147-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Taraskina |D A. |u B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Grunina |D M. |u B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zabotina |D A. |u B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nasyrova |D F. |u V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ivanov |D M. |u V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Krupitsky |D E. |u V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schwartzman |D A. |u B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 160/2(2015-12-01), 271-274 |x 0007-4888 |q 160:2<271 |1 2015 |2 160 |o 10517 | ||