caa a22 4500 605537313 CHVBK 20210128100856.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10517-015-3147-7 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3147-7 The Key Proteins of Dopaminergic Neurotransmission of Human Peripheral Blood Lymphocytes: Changed mRNA Level in Alcohol Dependence Syndrome [Elektronische Daten] [A. Taraskina, M. Grunina, A. Zabotina, F. Nasyrova, M. Ivanov, E. Krupitsky, A. Schwartzman] The expression of dopamine receptor (DRD), Nurr1 transcription factor (NR4A2), and α-sinucleine (SNCA) genes in peripheral blood lymphocytes is evaluated. The results indicate that alcohol dependence is associated with high expression of SNCA and DRD4 (signifi cantly higher than in the control group) and is not associated with changes in the work of NR4A2 and DRD3 genes. The levels of DRD3 and DRD4 mRNA form a positive linear correlation (p≤0.05). The expression of SNCA and DRD4 genes can serve as an important peripheral marker of alcohol dependence development, which is essential for antipsychotic therapy. Springer Science+Business Media New York, 2015 dopaminergic neurotransmission proteins nationallicence gene expression nationallicence real time quantitative polymerase chain reaction nationallicence peripheral blood lymphocytes nationallicence alcohol dependence syndrome nationallicence Taraskina A. B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia aut Grunina M. B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia aut Zabotina A. B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia aut Nasyrova F. V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia aut Ivanov M. V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia aut Krupitsky E. V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia aut Schwartzman A. B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 271-274 0007-4888 160:2<271 2015 160 10517 https://doi.org/10.1007/s10517-015-3147-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3147-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Taraskina A. B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia aut NATIONALLICENCE 700 1- Grunina M. B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia aut NATIONALLICENCE 700 1- Zabotina A. B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia aut NATIONALLICENCE 700 1- Nasyrova F. V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Ivanov M. V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Krupitsky E. V. M. Bechterev St. Petersburg Psychoneurological Research Institute, the Ministry of Health of Russia, St. Petersburg, Russia aut NATIONALLICENCE 700 1- Schwartzman A. B. P. Konstantinov St. Petersburg Institute of Nuclear Physics, National Center Kurchatov Institute, Gatchina, Leningrad region, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 271-274 0007-4888 160:2<271 2015 160 10517