caa a22 4500 605537348 CHVBK 20210128100857.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10517-015-3144-x doi (NATIONALLICENCE)springer-10.1007/s10517-015-3144-x Incidence of Autoantibodies to C1Q Complement Component in Women with Miscarriages and Autoantibodies to Phospholipids and Chorionic Gonadotropin [Elektronische Daten] [I. Menzhinskaya, L. Van'ko, M. Kashentseva, P. Kiryushchenkov, G. Sukhikh] Autoantibodies to C1q complement component are often detected in patients with autoimmune diseases. The complement system is involved in the pathophysiology of gestosis. The incidence of anti-C1q autoantibodies was studied in women with miscarriages and autoantibodies to phospholipids and chorionic gonadotropin. Serum C3 and C4 complement components and anti-C1Q autoantibodies (IgG) were measured by ELISA. The median levels of C3 and C4 in patients with miscarriages were lower than in healthy women. Anti-C1q autoantibodies were more often found in the patients than in controls; patients with autoantibodies to phospholipids formed a risk group. Median levels of anti-C1q autoantibodies were higher in the patients with autoantibodies to phospholipids and chorionic gonadotropin than in healthy women. Hence, activation of the complement system and hyperproduction of anti-C1q autoantibodies were unfolding in patients with miscarriages, mainly in the patients with autoantibodies to phospholipids. Springer Science+Business Media New York, 2015 autoantibodies to complement C1q component nationallicence antiphospholipid autoantibodies nationallicence autoantibodies to chorionic gonadotropin nationallicence miscarriage nationallicence Menzhinskaya I. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia aut Van'ko L. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia aut Kashentseva M. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia aut Kiryushchenkov P. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia aut Sukhikh G. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 260-263 0007-4888 160:2<260 2015 160 10517 https://doi.org/10.1007/s10517-015-3144-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3144-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Menzhinskaya I. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Van'ko L. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Kashentseva M. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Kiryushchenkov P. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Sukhikh G. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 260-263 0007-4888 160:2<260 2015 160 10517