caa a22 4500 605537364 CHVBK 20210128100857.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10517-015-3123-2 doi (NATIONALLICENCE)springer-10.1007/s10517-015-3123-2 Activity of Phosphate-Dependent Glutaminase in the Brain of Rats Exposed to Prenatal Hypoxia during Organogenesis [Elektronische Daten] [L. Gadirova, T. Agaev] We studied the effect of hypoxia (days 9-15 of pregnancy) on phosphate-dependent glutaminase activity in the brain of rat offspring aging 18 days and 1, 3, and 6 months. Activity of glutaminase significantly increased in mitochondria from the orbital, visual, and limbic cortex, hypothalamus, and midbrain of 17-day-old offspring. Activity of this enzyme in all brain regions increased at the age of 1 month, but significantly decreased in animals aging 3 and 6 months and prenatally exposed to hypoxia (during organogenesis). Changes in glutaminase activity in various structures of the brain are probably associated with activation of the glutamatergic and GABAergic systems and serve as an adaptive and compensatory reaction of the brain. Springer Science+Business Media New York, 2015 prenatal hypoxia nationallicence phosphate-dependent glutaminase nationallicence brain nationallicence Gadirova L. A. I. Karaev Institute of Physiology, National Academy of Sciences of Azerbaijan, Baku, Azerbaijan Republic aut Agaev T. A. I. Karaev Institute of Physiology, National Academy of Sciences of Azerbaijan, Baku, Azerbaijan Republic aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 187-189 0007-4888 160:2<187 2015 160 10517 https://doi.org/10.1007/s10517-015-3123-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3123-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gadirova L. A. I. Karaev Institute of Physiology, National Academy of Sciences of Azerbaijan, Baku, Azerbaijan Republic aut NATIONALLICENCE 700 1- Agaev T. A. I. Karaev Institute of Physiology, National Academy of Sciences of Azerbaijan, Baku, Azerbaijan Republic aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 187-189 0007-4888 160:2<187 2015 160 10517