caa a22 4500 605537372 CHVBK 20210128100857.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10517-015-3143-y doi (NATIONALLICENCE)springer-10.1007/s10517-015-3143-y Successive Administration of Streptococcus Type 5 Group A Antigens and S. typhimurium Antigenic Complex Corrects Elevation of Serum Cytokine Concentration and Number of Bone Marrow Stromal Pluripotent Cells in CBA Mice Induced by Each Antigen Separately [Elektronische Daten] [Yu. Gorskaya, T. Danilova, V. Grabko, V. Nesterenko] Administration of bacterial antigens to CBA mice induced an increase in serum concentration of virtually all cytokines with a peak in 4 h after administration of S. typhimurium antigens and in 7 h after administration of streptococcus antigens. In 20 h, cytokine concentrations returned to the control level or were slightly below it. In 4 h after administration of S. typhimurium antigens preceded 3 h before by administration of streptococcus antigens, we observed a significant decrease in serum concentrations of IFN-γ, IL-10, GM-CSF, IL-12, and TNF-α, in comparison with injection S. typhimurium antigens alone and IL-5, IL-10, GM-CSF, and TNF-α in comparison with injection of streptococcus antigens alone; the concentrations of IL-2 and IFN-γ, in contrast, increased by 1.5 times in this case. In 20 h after administration of S. typhimurium antigens, the number of multipotential stromal cells (MSC) in the bone marrow and their cloning efficiency (ECF-MSC) increased by 4.8 and 4.4 times, respectively, in comparison with the control, while after administration of streptococcus antigens by 2.6 and 2.4 times, respectively. In 20 h after administration of S. typhimurium antigens preceded 3 h before by administration of streptococcus antigens, these parameters increased by 3.2 and 2.9 times, respectively, in comparison with the control, i.e. the observed increase in the level of MSC count and ECF-MSC is more consistent with the response of the stromal tissue to streptococcus antigens. Thus, successive administration of two bacterial antigens corrected both serum cytokine profiles and MSC response to administration of each antigen separately, which indicates changeability of the stromal tissue in response to changes in the immune response. Springer Science+Business Media New York, 2015 immune response nationallicence successive administration of antigens nationallicence mesenchymal stem cells nationallicence cytokine profile of blood serum nationallicence Gorskaya Yu Laboratory of Immunity Regulation and Immune Tolerance, Moscow, Russia aut Danilova T. Laboratory of Microbiology of Latent Infections; N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia aut Grabko V. Laboratory of Immunity Regulation and Immune Tolerance, Moscow, Russia aut Nesterenko V. Laboratory of Immunity Regulation and Immune Tolerance, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 256-259 0007-4888 160:2<256 2015 160 10517 https://doi.org/10.1007/s10517-015-3143-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-3143-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gorskaya Yu Laboratory of Immunity Regulation and Immune Tolerance, Moscow, Russia aut NATIONALLICENCE 700 1- Danilova T. Laboratory of Microbiology of Latent Infections; N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Grabko V. Laboratory of Immunity Regulation and Immune Tolerance, Moscow, Russia aut NATIONALLICENCE 700 1- Nesterenko V. Laboratory of Immunity Regulation and Immune Tolerance, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 160/2(2015-12-01), 256-259 0007-4888 160:2<256 2015 160 10517