caa a22 4500 605537429 CHVBK 20210128100857.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10517-015-2846-4 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2846-4 Features of the Structure of the Circadian Rhythm of Blood Pressure and Heart Rate under Genetically Determined Hypertension in the Experiment [Elektronische Daten] [M. Blagonravov, V. Frolov, V. Goryachev, M. Azova] In SHR rats of different ages (22, 26, 30, 34, and 38 weeks), continuous 24-h telemetric monitoring of BP and HR was performed. The amplitude and power of oscillations of diastolic BP significantly decreased at the later stages of arterial hypertension (38 weeks), which was considered as a poor prognostic marker. We also observed a significant decrease in the mean daytime, nighttime, and maximum HR and mesor on weeks 30 and 34, but not on week 38, which can reflect triggering of the adaptive response followed by its exhaustion. Springer Science+Business Media New York, 2015 blood pressure nationallicence heart rate nationallicence circadian rhythm nationallicence arterial hypertension nationallicence spontaneously hypertensive rats (SHR) nationallicence Blagonravov M. Department of General Pathology and Pathophysiology, Medical Faculty, People's Friendship University of Russia, Moscow, Russia aut Frolov V. Department of General Pathology and Pathophysiology, Medical Faculty, People's Friendship University of Russia, Moscow, Russia aut Goryachev V. Department of General Pathology and Pathophysiology, Medical Faculty, People's Friendship University of Russia, Moscow, Russia aut Azova M. Department of General Pathology and Pathophysiology, Medical Faculty, People's Friendship University of Russia, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 723-725 0007-4888 158:6<723 2015 158 10517 https://doi.org/10.1007/s10517-015-2846-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2846-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Blagonravov M. Department of General Pathology and Pathophysiology, Medical Faculty, People's Friendship University of Russia, Moscow, Russia aut NATIONALLICENCE 700 1- Frolov V. Department of General Pathology and Pathophysiology, Medical Faculty, People's Friendship University of Russia, Moscow, Russia aut NATIONALLICENCE 700 1- Goryachev V. Department of General Pathology and Pathophysiology, Medical Faculty, People's Friendship University of Russia, Moscow, Russia aut NATIONALLICENCE 700 1- Azova M. Department of General Pathology and Pathophysiology, Medical Faculty, People's Friendship University of Russia, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/6(2015-04-01), 723-725 0007-4888 158:6<723 2015 158 10517