Effect of Diprotin A, an Inhibitor of Dipeptidyl Peptidase IV, on Immunological Parameters of Lymphocytes in Intact Animals and Animals with Experimental Autoimmune Process
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 605537461 | ||
| 003 | CHVBK | ||
| 005 | 20210128100857.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150401xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10517-015-2858-0 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2858-0 | ||
| 245 | 0 | 0 | |a Effect of Diprotin A, an Inhibitor of Dipeptidyl Peptidase IV, on Immunological Parameters of Lymphocytes in Intact Animals and Animals with Experimental Autoimmune Process |h [Elektronische Daten] |c [M. Robinson, E. Mel'nikova, V. Trufakin] |
| 520 | 3 | |a We found the peculiarities of the effects of dipeptidyl peptidase IV inhibitor diprotin A on immunological parameters of lymphocytes in lymphoid organs in intact animals and in animals with experimental autoimmune process. In intact animals, diprotin A increased cellularity of the thymus and spleen, number of CD4+, CD8+, and CD4+8+ thymocytes and CD3+ splenocytes and reduced cellularity of lymph nodes and the number of antibody-forming cells in the spleen. Diprotin A administered against the background of autoimmune process, reduced thymus cellularity, number of antibody-forming cells in the spleen, and number of CD4 and CD4+8+ thymocytes in comparison with the corresponding parameters of autoimmune process. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a lymphocyte |2 nationallicence | |
| 690 | 7 | |a diprotin A |2 nationallicence | |
| 690 | 7 | |a experimental autoimmune process |2 nationallicence | |
| 700 | 1 | |a Robinson |D M. |u Research Institute of Clinical and Experimental Lymphology, Siberian, Russia |4 aut | |
| 700 | 1 | |a Mel'nikova |D E. |u Research Institute of Clinical and Experimental Lymphology, Siberian, Russia |4 aut | |
| 700 | 1 | |a Trufakin |D V. |u Research Institute of Clinical and Experimental Lymphology, Siberian, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/6(2015-04-01), 769-771 |x 0007-4888 |q 158:6<769 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2858-0 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2858-0 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Robinson |D M. |u Research Institute of Clinical and Experimental Lymphology, Siberian, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mel'nikova |D E. |u Research Institute of Clinical and Experimental Lymphology, Siberian, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Trufakin |D V. |u Research Institute of Clinical and Experimental Lymphology, Siberian, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/6(2015-04-01), 769-771 |x 0007-4888 |q 158:6<769 |1 2015 |2 158 |o 10517 | ||